该【HIFU局部消融大鼠胰腺后组织学和糖代谢转归 】是由【niuwk】上传分享，文档一共【2】页，该文档可以免费在线阅读，需要了解更多关于【HIFU局部消融大鼠胰腺后组织学和糖代谢转归 】的内容，可以使用淘豆网的站内搜索功能，选择自己适合的文档，以下文字是截取该文章内的部分文字，如需要获得完整电子版，请下载此文档到您的设备，方便您编辑和打印。HIFU局部消融大鼠胰腺后组织学和糖代谢转归 Introduction: High-intensity focused ultrasound (HIFU) has been used as an effective noninvasive therapeutic approach for the treatment of various diseases. In recent years, HIFU has been investigated as a potential treatment option for pancreatic cancer, which is one of the most lethal cancers worldwide. However, little is known about the effects of HIFU on the pancreatic tissue structure and glucose metabolism. This study aimed to investigate the histological changes and glucose metabolism outcomes after local ablation of the pancreatic tissue with HIFU in rats. Materials and Methods: A total of 24 male Sprague-Dawley rats were enrolled in the study. They were divided into two groups: HIFU treatment group (n = 12) and control group (n = 12). The HIFU treatment group underwent HIFU-mediated local ablation of the pancreatic tissue, whereas the control group received no treatment. After 7 days, the rats were sacrificed and pancreatic tissue samples were collected for histological and biochemical analysis. The histopathological changes were analyzed using hematoxylin-eosin (H&E) staining, and glucose metabolism was assessed by measuring insulin and glucose levels in plasma. Results: The histological analysis revealed that HIFU treatment resulted in significant tissue damage, characterized by necrotic areas, cellular debris, and inflammatory cell infiltration. Moreover, the HIFU treatment group showed a significant decrease in the levels of insulin ( ± ng/mL) compared to the control group ( ± ng/mL). The glucose levels also decreased significantly in the HIFU treatment group ( ± mg/dL) compared to the control group ( ± mg/dL). Discussion: HIFU-mediated local ablation of the pancreatic tissue led to significant histological changes, including necrosis and inflammatory cell infiltration. These findings are consistent with previous studies that have reported similar histological changes after HIFU treatment. Moreover, the significant decrease in insulin and glucose levels suggests that HIFU treatment may have an impact on glucose metabolism. The decrease in insulin levels may be due to the destruction of pancreatic cells responsible for insulin production. The decrease in glucose levels may be a result of the decreased insulin secretion or the destruction of pancreatic cells responsible for glucagon secretion. Conclusion: This study provides insights into the effects of HIFU treatment on the histological structure and glucose metabolism of pancreatic tissue in rats. The findings suggest that HIFU-mediated local ablation results in significant tissue damage and alters glucose metabolism. Further studies are needed to investigate the long-term effects of HIFU treatment on glucose metabolism and its potential as a therapeutic approach for pancreatic cancer.
