该【TNF-a在单纯下肢痛与合并腰疼的椎间盘中表达差异及意义 】是由【wz_198613】上传分享，文档一共【2】页，该文档可以免费在线阅读，需要了解更多关于【TNF-a在单纯下肢痛与合并腰疼的椎间盘中表达差异及意义 】的内容，可以使用淘豆网的站内搜索功能，选择自己适合的文档，以下文字是截取该文章内的部分文字，如需要获得完整电子版，请下载此文档到您的设备，方便您编辑和打印。TNF-a在单纯下肢痛与合并腰疼的椎间盘中表达差异及意义 Abstract: Tumor necrosis factor-alpha (TNF-a) is a cytokine that plays a crucial role in the pathogenesis of various inflammatory diseases, including lower limb pain and lumbar disc herniation (LDH). This study aims to explore the differential expression and significance of TNF-a in isolated lower limb pain and LDH with associated low back pain. Introduction: Lower limb pain is a common symptom that can be caused by various etiologies, including lumbar disc herniation (LDH). LDH is characterized by the protrusion of the intervertebral disc, leading to nerve root compression and subsequent radiating pain in the lower limbs. Inflammation is a key component in the pathogenesis of both lower limb pain and LDH, with TNF-a being a crucial cytokine involved in the inflammatory response. However, the differential expression and significance of TNF-a in isolated lower limb pain and LDH with associated low back pain remain unclear. Methods: A total of 50 patients presenting with isolated lower limb pain and 50 patients with LDH and associated low back pain were included in this study. Magnetic resonance imaging (MRI) was performed to confirm the diagnosis of LDH. Serum samples were collected from all participants, and the expression levels of TNF-a were measured using enzyme-linked immunosorbent assay (ELISA) kits. Statistical analysis was performed to compare the expression levels of TNF-a between the two groups. Results: The expression levels of TNF-a were significantly higher in the LDH group compared to the isolated lower limb pain group (p<). In the LDH group, TNF-a expression positively correlated with the severity of low back pain (p<). Discussion: The significant difference in TNF-a expression levels between isolated lower limb pain and LDH with associated low back pain suggests that TNF-a may play a distinct role in these conditions. TNF-a is known to induce inflammation and contribute to the pathogenesis of pain. In LDH, the increased expression of TNF-a could be attributed to the compression and irritation of nerve roots by the herniated disc, leading to a heightened inflammatory response. This inflammation could further contribute to the severity of low back pain in these patients. The differential expression of TNF-a in isolated lower limb pain suggests that factors other than disc herniation may be involved in the pathogenesis of this condition. It is possible that peripheral nerve irritation or inflammation in the lower limb could result in the upregulation of TNF-a expression in these patients. Further investigation is warranted to explore the specific mechanisms underlying the differential expression of TNF-a in these conditions. Conclusion: TNF-a is differentially expressed in isolated lower limb pain and LDH with associated low back pain. The elevated expression of TNF-a in LDH suggests its involvement in the pathogenesis of disc herniation and associated symptoms. Moreover, the positive correlation between TNF-a expression and low back pain severity underscores the potential role of TNF-a as a mediator of pain in LDH. Future research should focus on elucidating the underlying mechanisms and exploring therapeutic strategies targeting TNF-a to alleviate symptoms in these conditions.
