该【生物材料Biomaterials省公开课一等奖全国示范课微课金奖PPT课件 】是由【286919636】上传分享，文档一共【36】页，该文档可以免费在线阅读，需要了解更多关于【生物材料Biomaterials省公开课一等奖全国示范课微课金奖PPT课件 】的内容，可以使用淘豆网的站内搜索功能，选择自己适合的文档，以下文字是截取该文章内的部分文字，如需要获得完整电子版，请下载此文档到您的设备，方便您编辑和打印。Biomaterials 1/36 Biomaterials Non-viable material used in a medical device intended to interact with biological systems Material intended to interact with biological systems 2/36 Biomaterials Science Physical and biological study of materials and their interaction with the biological environment Synthesis Optimization Testing Biology of host-material interactions 3/36 Ratner (1993) characterized body response to these materials as “blah” Non specific Sluggish kinetics Broad spectrum of active processes occurring Proteins – 200 + to choose from Cells (neutrophils, macrophages, platelets) well adapted to respond to these proteins 4/36 What we get What we really want 5/36 Development of engineered surfaces that elicit rapid and highly precise reactions with cells and proteins Tailored to specific application Resistance to blood clotting Resistance to bacterial infection Normal uncomplicated healing 6/36 Biomaterials History “Hero surgeons” Ridley and IOLs Hip and knee prostheses – Canadian connection Kidney dialysis Breast implants Vascular grafts Stents 7/36 The Terylene, Orlon or nylon cloth is bought from a draper’s shop and cut with pinking shears to the required shape. It is then sewn with thread of similar material into a tube and sterilized by autoclaving before use. 8/36 The Current State of Affairs Medical devices are regulated by the FDA Some devices are grandfathered based on being available prior to the legislation introduction Classified based on safety and potential impact to human health 9/36 Materials Commonly Used in Biomaterials Applications Synthetic Polymers Hydrogels Polyurethanes Silicone based materials Teflon Dacron Poly (ethylene oxide) Degradable materials Natural Polymers and Other Natural Materials 10/36
