The Organic Chemistry of Drug Synthesis VOLUME 1 - DANIEL LEDNICER.pdf

anic Chemistry
of Drug Synthesis
Volume 1
DANIEL LEDNICER
Chemical Research
Mead Johnson & Co.
Evansville, Indiana
LESTER A. MITSCHER
The University of Kansas School of Pharmacy
Department of Medicinal Chemistry
Lawrence, Kansas
with a Glossary by Philip F. vonVoigtlander
The pany
A WILEY-INTERSCIENCE PUBLICATION
JOHN WILEY & SONS
New York • Chichester • Brisbane • Toronto
Copyright © 1977 by John Wiley & Sons, Inc.
All rights reserved. Published simultaneously in Canada.
Reproduction or translation of any part of this work beyond
that permitted by Sections 107 or 108 of the 1976 United States
Copyright Act without the permission of the copyright owner
is unlawful. Requests for permission or further information
should be addressed to the Permissions Department, John
Wiley & Sons, Inc.
Library of Congress Cataloging in Publication Data:
Lednicer, Daniel, 1929-
anic chemistry of drug synthesis.
"A Wiley-Interscience publication."
1. Chemistry, Medical and pharmaceutical.
2. Drugs. 3. Chemistry, Organic. I. Mitscher,
Lester A., joint author. II. Title.
615M91 76-28387
ISBN 0-471-52141-8
Printed in the United States of America
10 9
To
Beryle and Betty
whose steadfastness made that which follows e real
The three princes of Serendip, Balakrama, Vijayo, and Rajahsigha,
as they traveled "...were always making discoveries, by accident
and sagacity, of things they were not in quest of...n*
^Horace Walpole, in a letter of January 28, 1754, as quoted in
"The Three Princes of Serendip," by E. J. Hodges, Atheneum, .,
1!K)4
vii
Preface
There exists today an abundance of excellent texts covering the
various aspects anic chemistry. The student of medicinal
chemistry can choose among any of a number of first-rate exposi-
tions of that field. The reader who is primarily interested in
the synthesis of some particular class of medicinal agents, how-
ever, will often find that he must consult either the