Conclusions:
JJSJS reduces the fibrotic degree of rats hepatic tissue significantly which means that this formular has powerful anti-fibrosis effect.
JJSJS inhibits expression of TGF-β1 and Smad2/3 in hepatic tissues and increases the expression of is better than the has powerful anti-fibrotic effect through inhibiting the TGF-β/Smad pathway.
There isn’t different between the JJSJS and the colchicines in decressing the expression of TNF-α in hepatic tissue in the fibrosis rats.
JJSJS decresses the expression of TIMP-1mRNA,TIMP-2mRNA and MMP-2mRNA in hepatic tissue in the fibrosis rats, so it suppresses ECM’s degradation process by decresses the expression of MMP-2mRNA.
It has not difference between the JJSJS and the insect drugs group in decressing the expression of TIMP-1mRNA.
Keywords: jiajiansanjiasan(JJSJS); hepatic fibrosis, TGF-β/Smad pathway, MMPs/TIMPs system
英文缩略词对照表
缩略词 英文全称 中文全称
ACE-I Blood vessel tense element transformation enzyme inhibitor
血管紧张素转换酶抑制剂
ALB albumin 白蛋白
ALP Alkaline phosphatase 碱性磷酸酶
ALT alanine amiotransferase 丙氨酸氨基转移酶
AP-1 activator protein 1 活化蛋白质 1
α-SMA alpha-sooth muscle actin a-平滑肌肌动蛋白
BSA bovine serum albumin 牛血清白蛋白
CCL4 carbon tetrachloride 四氯化碳
Cl chlorine 氯
CDK Cyclin dependent kinase 细胞周期蛋白依赖性激酶
DAB diaminobenzidine 二氨基联苯胺
DEPC Diethyl pyrocarbonate 焦碳酸二乙酯
ECM Extra-cellular matrix 细胞外基质
ET Endothelin 内皮素
FN Fibronectin 纤维连接蛋白
GGT Gamma-glutamyl tranzpehtidaze γ谷氨酰转肽酶
GPT Glutamic-pyruvic transaminase 谷丙转氨酶
HA hyaluronic acid 透明质酸
HBsAg hepatitis B surface antigen 乙型肝炎表面抗原
HBV hepatitis B virus 乙型肝炎
HC Hepatocyte 肝细胞
HCV hepatitis C virus 丙型肝炎
HE Hematoxyclin and eoxsin 苏木精和伊红(染色)
HEV hepatitis E virus 戊型肝炎
HRP horse radish peroxidase 辣根过氧化物酶
HSC Hepaticstellatecells 肝星状细胞
HYP hydroxyproline 羟脯氨酸
IB indirect Bilirubin 间接胆红素
IFN-α Interferon-α α-干扰素
IFN-γ Interferon-γ γ-干扰素
IL Interleukin 白细胞介素
IV-C Type IV Collagen IV 型胶原
KC Kupffer cell 肝枯否氏细胞
LAP leucineam i
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