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目录
中文摘要······································································1 英文摘要······································································4 前言··········································································7 第一章 G-2407-4 口腔喷雾剂的处方前研究·······································9 一、仪器与试药·······························································9 1. 实验仪器··································································9
2. 药品与试剂································································9 二、方法与结果································································9 1. 制剂规格的确定····························································9
2. 紫外分析方法的建立························································9
检测波长的选择···························································9
标准曲线和线性范围·······················································10
日内日间精密度··························································11
重复性··································································11
3. 溶解度的测定·····························································11
4. 给药装置的选择及质量考察·················································11
给药装置的选择··························································11
喷雾泵的质量考察························································11
室温下喷雾泵的每喷剂量考察············································12
40℃,RH75%条件下喷雾泵的每喷剂量考察 12
25℃,%条件下喷雾泵每喷剂量的考察 13
40℃,RH75%条件下喷雾泵的密闭性考察 13
25℃,%条件下喷雾泵的密闭性考察 14
喷雾泵的装量考察······················································14
喷雾泵的每瓶总喷次考察················································15
三、结论·····································································15
四、讨论·····································································16 第二章 G-2407-4 口腔喷雾剂的处方优化·········································17 一、仪器与试药··················································
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