VEC胰岛素抵抗与FKBP12基因表达关系的研究.pdf

第三军医大学
硕士学位论文
VEC胰岛素抵抗与FKBP12基因表达关系的研究
姓名:王耀辉
申请学位级别:硕士
专业:内科学(心血管)
指导教师:杨成明
20040501
第三军医大学硕士学位论文
英文缩写与中文对照一览表

缩写英文全称中文全称
Ins Insulin 胰岛素
InsR Insulin receptor 胰岛素受体
IR Insulin resistance 胰岛素抵抗
IRS Insulin-resistance syndrome 胰岛素抵抗综合征
IGT Impaired glucose tolerance 葡萄糖耐量障碍
AS Atherosclerosis 动脉粥样硬化
CVD Cardiovascular disease 心血管疾病
VEC Vascular endothelial cell 血管内皮细胞
ECGF Endothelial cell growth factor 内皮细胞生长因子
GIR Glucoseinfusionrate 血糖钳的输注速率
ECF Endothelial cells function 内皮细胞功能
NO Nitrogen monoxide 一氧化氮
eNOS Endothelial nitricoxide synthase 内皮型一氧化氮合酶
RyR Ryanodine receptor 理阿诺碱受体
IP3R Ins(1,3,5)P(3) receptor 三磷酸肌醇受体
FKBP12 FK506 binding protein 12 FK506 结合蛋白 12
FK506 binding protein FK506 结合蛋白
mRNA Messengerribonucleic acid 信使核糖核酸
RT-PCR Reverse Transcription PCR 逆转录 PCR
PCR Polymerase chain reaction 多聚酶链反应
GC Growth Curve 生长曲线
TGF- R Transforming growth factor-beta receptor 转化生长因子- 受体
DEPC-DW Diethypyrocabonate-Distilled water 焦碳酸二乙酯处理蒸馏水
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第三军医大学硕士学位论文
BS Bovine Serum 牛血清
EB Ethidium bromide 溴化乙锭
plementary DNA 互补 DNA

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第三军医大学硕士学位论文
Stuby on the relationship between insulin-resistance and
the changes of FKBP12 expression at the transcription
level in VEC proliferation

Abstract

Hypertension,diabetes and cardiovascular disease (CVD) spring from a "common
soil" that is insulin-resistance (IR). The insulin-resistance syndrome (IRS) consists of
glucose intolerance, hyperinsulinemia, dyslipidemia (high triglyceride and low high-density
lipoprotein [HDL] cholesterol levels), and hypertension. Factors associated with insulin
resistance, which was found to be a risk factor for development of hypertension, precede
hypertension. Resistance to insulin-stimulated glucose uptake is present in the majority of
patients with impaired glucose tolerance (IGT) or non-insulin-dependent diabetes mellitus
(NIDDM) and in approximately 25% of nonobese individuals with normal