Multilayered Nanoparticles for Drug/Gene Delivery in Nanomedicine OSC Drug Delivery Workshop November 14, 2005 James F. Leary, . SVM Professor of Nanomedicine Professor of Basic Medical Sciences and Biomedical Engineering Member: Purdue Cancer Center; Oncological Sciences Center; Bindley Biosciences Center; Birck Nanotechnology Center Purdue University, W. Lafayette, IN 47907 Email: ******@ Our Goal is to Design Autonomous Nanomedical Systems Definition: Self-guiding, adaptive, ponent systems on the nanoscale for diagnostic and therapeutic prevention or treatment of disease Value: These “smart” nanomedical systems can deal with changing conditions, are error-correcting, and can provide proper dose of therapeutic response on a cell-by-cell basis Nanomedicine Concept of Regenerative Medicine “Fixing cells one cell at-a-time” Conventional cancer therapies try to cut out the bad cells (surgery), burn them out (radiation therapy), or poison the bad cells faster than the good cells (chemotherapy)! Conventional medicine removes diseased cells and does not attempt to fix them. Nanomedicine attempts to make smart decisions to either remove specific cells by induced apoptosis or repair them one cell-at-a-time (regenerative medicine). Single cell treatments will be based on molecular biosensor information that controls subsequent drug delivery to that single cell. What is Nanomedicine? Beyond the obvious application of nanotechnology to medicine, the approach is fundamentally different than conventional medicine: Nanomedicine uses “nano-tools”(. smart nanoparticles) that are roughly 1000 times smaller than a cell (knives to microsurgery to nanosurgery …) Nanomedicine is the treatment or repair (regenerative medicine, not just killing of diseased cells) of tissues ans, WITHIN individually targeted cells, cell-by-cell (a nano “bottoms up”, rather than top-down approach) Nanomedicine bines use of molecular biosensors to provide for feedback control of
