作者:张国民,莫新民,刘慧萍,陶灵霞,宁伟巍 【摘要】 目的:观察疏肝和胃丸抑制大鼠胃酸、胃蛋白酶分泌的作用。方法:将40只大鼠随机分为对照组、模型组、胃苏冲剂组、疏肝和胃丸组,每组10只。末次灌胃后,除对照组外的大鼠均采用幽门结扎法复制大鼠胃溃疡模型,观察各组大鼠胃酸、胃蛋白酶分泌的变化。结果:疏肝和胃丸组大鼠胃酸、胃蛋白酶的分泌水平明显降低,与模型组、胃苏冲剂组比较均有显著差异(p<)。结论:疏肝和胃丸具有显著抑制胃酸、胃蛋白酶分泌的作用。【关键词】 胃酸;胃蛋白酶; 疏肝和胃丸; 胃苏冲剂;大鼠 abstract objective:to observe the effects of shugan hewei pill on inhibiting the secretion of gastric acid and pepsin of rats with gastric ulcer. methods:40 rats were randomly divided into normal group, model group, weisu granule treatment group, shugan hewei pill treatment group. model rats were induced by ligating pylorus. the contents of gastric acid and pepsin of all groups were dectected. pared with model group and weisu granule treatment group, the contents of gastric acid and pepsin were obviously decreased in shugan hewei pill treatment group(p<). conclusion:shugan hewei pill has obvious effects on inhibiting the secretion of gastric acid and pepsin of rats with gastric ulcer. key words gastric acid; pepsi
n; shugan hewei pill; weisu granule rat 消化性溃疡一直都是临床上的常见病和多发病,呈世界性分布,约有10%的人一生中患过此病,近年来国内外运用中医药治疗已经取得较好疗效[1]。现代医学研究认为“无酸就无溃疡”,消化性溃疡的最终形成是由于胃酸-胃蛋白酶自身消化所致,这一概念在“hp时代”仍未改变。疏肝和胃丸是经过数十年临床研究,反复筛选而成,主要由柴胡、法半夏、白芍、枳壳、木香、香附等组成,具有疏肝理气、和胃止痛之功效,临床用于治疗胃溃疡。本文通过观察其对大鼠胃酸及胃蛋白酶分泌的影响,来初步探讨其作用机理。 1 材料与方法 实验材料 实验动物 大鼠40只,雌雄各半,体重为(180~200)g,由湖南中医药大学动物实验中心提供。 药品与试剂 疏肝和胃丸, 由湖南
【医学论文】疏肝和胃丸抑制胃溃疡大鼠胃酸和胃蛋白酶分泌作用的实验研究 来自淘豆网m.daumloan.com转载请标明出处.
