兔胸部爆炸伤后血液高凝状态的实验研究.doc

兔胸部爆炸伤后血液高凝状态的实验研究
作者:初向阳,侯晓彬,张连斌,薛志强,马克峰作者单位:(解放军总医院胸外科,北京 100853)
【摘要】目的通过对兔胸部爆炸伤后血液流变学变化规律的研究,探讨伤后血液高凝状态对肺脏等脏器功能的影响。方法健康中国家兔随机分为对照组和伤后5、30分钟、1、3、6小时5个时相点致伤组,观察血液流变学及肺组织病理学动态变化。结果兔胸部爆炸伤后5分钟全血黏度、血浆黏度、红细胞聚集指数、血浆纤维蛋白原含量及红细胞变形性均低于正常对照组,30分钟以后上述指标明显升高,3小时后达峰值,与正常对照组相比有非常显著统计学意义(P<),伤后6小时虽有所下降,但仍高于正常对照组(P<);肺组织病理学变化与血液流变学变化基本一致。结论兔胸部爆炸伤后血液流变学特性明显改变,出现血液高凝状态,血液黏滞性显著增加,从而加重微循环障碍而导致脏器功能损伤。
【关键词】爆炸伤;胸部损伤;高凝状态;微循环
Study on blood hypercoagulability after explosive injury of chest in rabbits
CHU Xiangyang,HOU Xiaobin,ZHANG Lianbin,et al.
(Department of Thoracic Surgery,PLA General Hospital,Beijing 100853,China)
Abstract: Objective To investigate the changes of hemorrheologic characteristics and discuss blood hypercoagulability an
d its significance for pulmonary function in rabbits following explosive injury of Rabbits were subjected to chest explosive were randomly divided into control group and injury injury group was further divided into five groups according to the duration time after characteristics was examined by eter histologic changes of the lung were examined at 1/12,,1,3,6 hours after Five minutes after explosive injury,the whole blood viscosity,the plasma viscosity,the index of erythrocyte aggregation,plasma fibrinogen content and the index of erythrocyte deformability pared with the control group,but increased after 30 minutes and reached maximum at 3 hours after injury(P<).The whole blood viscosity,the plasma viscosity,the index of erythrocyte aggregation and plasma fibrinogen content were lower 6 hours after injury but still higher than that of control group(P<).Hemorrheologic characteristics was correlated with the severity of lung The hemorrheologic characteristics change significantly after explosive injury of chest,and blood hypercoagulability may cause damage to microcirculation and lead to dysfuntion of one or ans,even MSO