前列腺病变与性激素受体表达的分析.docx

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々刈腺疗变与性激素受体表达的研究 中文提要
中文提要
目的:定性分析研究性激素受体AR、ER、PR在前列腺增生和前列腺癌中的阳性表达,为激素治疗前列腺癌和预后判断提供一定的临床依据。
方法:采用免疫组化二步法即DAKO Envision-二步法,分析30例前列腺增生(BPH) 与32例前列腺癌(Pea)标本,PAR、ER、PR的阳性表达定性分析,结合Pea患者术后生存期临床随访数据,采用数学统计方法进行x2检验,得出结果。
结果:30例BPH组AR、ER和pI滚达的阳性数分别为24例、10例和6例;32例Pea
组AR、ER和PR表达的阳性数分别为18例、14例和2例,两组在性激素受体阳性数表
达上的差导无显著性。随访30例Pea患者术后的生存期表明:AR表达阳性者平均生存
。#
,,两者在术后平均生存时间上差异有统计学的意义。
结论:BPH和Pea患者在性激素受体表达上的差异无显著意义;Pca患者中AR表达阳性者平均生存时间长于AR阴性者,后者的预后较差,对AR阴性者行激素治疗效果不确定。
关键词:雄激素受体;雌激素受体;孕激素受体;前列腺增生;前列腺癌
作 者:丁涛
指导教师:车文骏教授
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Expression of androgen receptor,oestrogen receptor and progesterone receptor in prostate cancer and benign prostate hyperplasia tissues
Abstract
Objective:To investigate the relationship between the androgen receptor(AR), oestrogen receptor(ER)and progesterone receptor(PR)by assaying the distribution of those three receptors on both the BPH and Pea tissues,then to explore the difference ofthe effect ofhormonal treatment betw∞n the AR positive and AR negative Pea patients.
Methods:First to observe the AR PR and ER expressed in 30 cases of BPH and 32 CaseS of Pca tissues through DAKO Envision methods,bined the survival time of the Pea pmiems accepted hormonal treatment to get the result.
Results:There am 24 AR positive ER positive cases and 6 PR positive cases in 30 BPH pmiems,and there are 1 8 AR positive cases,14 ER positive cases and 2 PR positive cases in 32 Pea is no significant difference between the two group fP>).The survival time ofthe Pea patients expressed and not expressed AR is and AR positive patients live longer than the AR negative patiems fP<).
Conclusions:These three receptors can’t result in Pea and the effect of hormonal
treatment on AR negative Pea patients is not certain.
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