系统性红斑狼疮课件.ppt

SYSTEMIC LUPUS  ERYTHEMATOSUS瑞金医院肾脏科李晓
Introduction
SLE is a chronic, usually life-long, potentially fatal autoimmune disease characterized by inflammation in many an monly involved skin and kidney.
Introduction
SLE is associated with the production of autoantibodies reactive with nuclear, cytoplasma and cell membrane antigens.
Introduction
fatigue
anemia
fever
rashes
sun sensitivity
alopecia
arthritis
pericarditis
pleurisy
vasculitis
nephritis
central nervous system disease
Introduction
F:M=7-10:1
Child-bearing age ( 13 ~ 40 years old)
Prevalence in women
China 113 per 100,000
USA 50 per 100,000
Etiology
ics HLA-DRw2 and HLA-DRw3
Virus type C viruses isolated
Hormone estrogens (androgens)
Environment ultraviolet light
Drugs procainamide, alpha-methyldopa,
D-penicillamine, quinidine, ...
Pathogenesis
The deposition of DNA-anti-DNA plexes
Antibodies to erythrocytes, granulocytes, lymphocytes, and macrophages
ic Environmental

(viral,bacterial,parasite)

3. Metabolic light
B cell proliferation
(nucleic acids,IC,
cellular debris) B cell differentiation
ic Autoantibody production
-lymphocyte -nuclear
+Antigen
Tissue deposition
Inflammation
Pathology(1)
Hematoxylin bodies These basophilic staining bodies are nuclear debris, often associated with antinuclear antibody, and represent a correlate of the LE cell in vivo.
Pathology(2)
The spleen has “union skin lesions”, concentric fibrosis of the walls and surrounding tissues of the central and penicilliary arteries.