固体脂质纳米粒的研究及应用.doc

固体脂质纳米粒的研究及应用
刘春喜1,张娜1*
(,济南 250012;)
摘要
自Müller 等人首次提出固体脂质纳米粒(solid lipid nanoparticles, SLN) 以来,SLN作为一种新型的脂质药物传输载体而备受关注。SLN用生理相容性的脂质或类脂质等常用的药剂辅料制备而成,综合了其他微粒传输系统如聚合物纳米粒、脂肪乳和脂质体的种种优点,包括物理稳定性高;防止药物降解,提高药物稳定性;缓释性能好,耐受性强等等。此领域的研究表明,在最佳条件下,SLN可适用于疏水或亲水性药物的传递,从而实现最佳微粒载体系统的要求。本文将综述SLN在基因传递、蛋白多肽类药物非注射给药、难溶性药物增溶及靶向给药系统中的研究和应用。
关键词:固体脂质纳米粒;基因传递;蛋白多肽类药物非注射给药;难溶性药物增溶;靶向给药系统
Studies and applications on Solid lipid nanoparticles
LIU Chun-xi1, ZHANG Na1*
(1. School of Pharmaceutical Science, Shandong University, Ji’nan 250012, China)
Abstract
Since their first description by Müller et al., solid lipid nanoparticles (SLN) have attracted increasing attention as an efficient and non-toxic alternative lipophilic colloidal drug carrier prepared mon pharmaceutical excipients such as physiological fatty substance or lipid. Solid lipid bine the advantages of polymeric nanoparticles, lipid emulsions and liposomes, such as physical stability, protection of incorporated labile drugs from degradation, controlled release, excellent tolerability and so on, while simultaneously avoiding their research work developed in the area confirms that under optimized conditions, they can be produced to incorporate hydrophobic or hydrophilic molecules and seem to fulfill the requirements for an optimum particulate carrier system. In this article, the applications of SLN in gene d