咪唑斯汀缓释片的释放度研究.doc

咪唑斯汀缓释片的释放度研究
孙建绪1 刘亚琴2 胡音1 高永良1
(1军事医学科学院毒物药物研究所,北京100850;2国家发改委药品价格评审中心,北京100045)
[摘要]目的:对制备的咪唑斯汀缓释片进行体外释放度研究。方法:采用比较法对不同的释放介质进行考察。结果:、%、5小时大于80%。结论:本品在上述三种介质中体外释放基本一致,其释放度不受释放介质pH值的影响,达到了设计要求。
[关键词] 咪唑斯汀缓释片处方释放度含量测定
[中图分类号][文献标识码][文章编号]
In vitro evaluation of Sustained-release Tablet of Mizolastine
SUN Jian-xu1 LIU Ya-qin2 HU Yin1 GAO Yong-liang1
( of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China; 2. Evaluation Center of Drug Pricing National Development and mission, Beijing 100045, China)
[Abstract] Objective:To evaluate dissolution in vitro of sustained-release tablet of mizolastine. Methods:The dissolution behaviors of sustained-release tablet of mizolastine, were evaluated in three different medias as ,purwater PBS (pH )solution. Results:In vitro evaluation indicated that it can release more than 60% after two hours and more than 80% after five hours in ﹒L-1HCL, pure water, PBS() solution Conclusion: Sustained-release tablet of mizolastine were expected to sustained-release effectiveness on this formulation and technology, and have a good stability; the developmental research of sustained-release tablet of mizolastine support quantity of data for pharmaceutical engineering research. The release behaviors in different medias were uniform and Ph-indepe