Microdomains,Inflammation,andAtherosclerosisReporter:ChongHuang(黄冲)Supervisor:ChaokeTang(唐朝克教授)May19,2016InstituteofCardiovasculardisease,KeyLaboratoryforArteriosclerologyofHunanProvince,UniversityofSouthChina*-Thomas,:11Background*Background3LDL-CHDL*contentWhyCholesterolMattersMembraneCholesterolandLipidRaftMicrodomainsMicrodomainCholesterolRegulation:RoleofEffluxCholesterolandImmuneCellProliferationandMigrationT-CellActivationandTRegulatoryCells:RoleofMicrodomainsAutoimmunityandCholesterolHomeostasis1*WhyCholesterolMatters1*2*MembraneCholesterolandLipidRaftMicrodomains2*lipidraftGlycerophospholipidssphingomyelinFC(dynamic)planarlipidraftinvaginatedlipidraft(caveolae)2*Lipidraft:eNOSSR-B1Rasmicrodomains:Golgi,mitochondria,lysosomes,lipiddroplets2*
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