LTP与PTSD发病机制的相关性及研究进展 杨姝石玉秀 (,,辽宁沈阳110001) 【摘要】创伤后应激障碍(PTSD)是指由于异常威胁性或灾难性心理创伤导致延迟出现和长期持续的精神障碍。长时程增强(LTP)为高频刺激突触前神经元后,在突触后神经元上纪录到的电位增大并维持相当长的时间。LTP是目前公认的理想代表学忆功能的电生理指标, LTP受体主要分为NMDA型和非NMDA型,而且大量研究证实LTP相关酶类及营养物质在LTP的形成及维持过程中起重要作用。在恐惧条件反射的形成过程中,其神经网络内(如杏仁核等)发生LTP,表明LTP是反应PTSD发生机制的重要指标。因此,通过研究影响LTP发生及维持的因素,可能进而推测出治疗PTSD的方法。 【关键词】创伤后应激障碍,长时程增强 The relationship and research progress of the LPT with the Pathogenesis of PTSD Yangshu ,shiyuxiu (, of Histology and Embryology,China Medical University,Shenyang 110001 China) 【Abstract】 Post-traumatic stress disorder(PTSD)is an anxiety disorder that can develop after exposure to one or more traumatic events threatened or caused grave physical harm. Long term potentiation (LTP) is for the high-frequency stinulation of presynaptic neurons,the postsynaptic neurons in the record to the potential increase and maintain for a long time. LTP is widely recognized as the electrophysiological parameters which is represent learning and memory function. LTP is divided into NMDA receptor type and non-NMDA-type, and numerous studies confirm that LTP-related enzymes and nutrients in the formation and maintenance of LTP may play an important role in the process. In fear conditioning in the formation of the work (such as the amygdala, etc.) occur LTP, that LTP is the mechanism of reaction an important i
