多潘立酮分散片的制备及性能考察.docx

多潘立酮分散片的制备及性能考察.docx多潘立酮分散片的制备及性能考察』fNewDrugs2005,,王静,刘伟娜(河北医科大学药学院1实验中心,2药剂教研室,石家庄050017)[摘要]目的:制备多潘立酮分散片,考察辅料对其溶出速度,:以崩解时限和可压性为指标进行单因素考察,以选择适宜的填充剂,崩解剂和润滑利用量;以溶ns速度,崩解时限及混悬液稳定性为指标从正交试验设计中确定最佳处方,:所选处方压片制利外观光洁,在30s内完全崩解,药物溶出迅速,:崩解剂的用量,加入方法,黏台剂浓度等因素对多潘立酮分散片的性质有明显影响,混悬液稳定性受原药,辅料粒度的影响较大.[关键词]多潘立酮;分散片;正交试验;溶出度[中图分类号];[文献标识码]AL文章编#]1003—3734(2005)07—0873—03PreparationandcharacterizationofdomperidonedispersibletabletsZHAOXing—IXL,WANGJing,LIUWei—na(ICentreQ厂Laboratory,2DepartmentofPharama-eutics,SchoolofPharmacy,HebeiMedicalUniversity,Shijiazhuang050017,China)[AbstractlObjective:Topreparedomperidonedispersibletabletsandinvestigateadditionsaffecteddissolutionrate,disintegrationtimeandsuspensibilityordertochoosesuitablefiller,disintergrantsandtheMethods:,disintegrationtimeandthesuspensibilityasindices・Theinvit「:Thetabletspreparedwerefineinappearance,disintegaratedwithin30s4hesuspensionscreenedthroughthe710-・Conclusion:Thequalityofthedispersibletabletsweremostlyrelatedtotheamoiintjhemethodusedofdisintergrantsandtheconcentrationofadhesionagent・;dispersibl