T淋巴细胞亚群对CAF方案同步放化疗治疗乳腺癌疗效探究.docx

T淋巴细胞亚群对CAF方案同步放化疗治疗乳腺癌疗效探究.docxT淋巴细胞亚群对CAF方案同步放化疗治疗乳腺癌疗效探究【摘要】目的:探讨应用不同阿霉素剂量的CAF方案同步放、化疗治疗中晚期乳腺癌治疗后T淋巴细胞亚群的免疫功能的变化及其与病情的关系。方法:采用单克隆抗体间接免疫荧光法对中晚期乳腺癌病人治疗后T淋巴细胞亚群检测结果进行比较。结果:CAF方案放化疗后A组和B组比较T淋巴细胞亚群各项指标均无明显动态变化,A组和B组中晚期乳腺癌病人T淋巴细胞亚群各项指标与C组比较均明显降低。结论:环磷酰胺(600mg/m2,第1、8天),阿霉素剂量为(40mg/m2,第1天),5-氟尿喘噪(500mg/m2,第1天)方案同步放、化疗为最佳CAF方案。可以减轻化疗及放射性损伤,提高患者生存率,建议广泛普及应用。【关键词】中晚期乳腺癌;同步放化疗;CAF方案【中图分类号】R737【文献标识码】A【文章编号】1004-7484(2013)05-0012-02StudyofTlymphocytesubsetswithConcurrentchemoradiotherapyofCAFchemotherapyinpatientswithadvancedbreastcancer[Abstract]Objective:ToanalyzethefunctionalchangesofTlymphocytesubsetswithConcurrentchemoradiotherapyofCAFchemotherapyindifferentdoxorubicindoseforadvancedbreastcanceranditsrelationshipwiththedisease・Methods: usingmonoclonalantibodybyindirectimmunofluorescencetodetectTlymphocytesubsetsinthetreatmentofpatientswithadvaneedbreastcancer・Results:paredwiththeindexofTlymphocytesubsetswerenotsignificantlychange,:cyclophosphamide(600mg/m2,thefirst1,8days),doxorubicindose(40mg/m2, firstdays), 5-fluorouracil(500mg/m2,firstdays),chemotherapyisthebestsolutiontothesynchronizationontheCAFscheme・Canreducethechemotherapyandradiationdamage,improvethesurvivalrateofwideapplication,suggestions・[Keywords】Inadvancedbreastcancer;Concurrentchemoradiotherapy;CAFchemotherapy中晚期乳腺癌病人免疫功