Restorative effect and mechanism of mecobalamin on sciatic nerve crush injury in mice.pdf

1979NEURAL REGENERATION RESEARCHNovember 2014, Volume 9, Issue 22 orative effect and mechanism of mecobalamin onsciatic nerve crush injury in miceDepartment of Orthopedics, Wuxi No. 2 People’s Hospital, Wuxi, Jiangsu Province, ChinaLin Gan and Minquan Qian contributedequally to this author:Wei Du, Department of Orthopedics, WuxiNo. 2 People’s Hospital, 68 ZhongshanRoad, Wuxi 214002, Jiangsu Province,China, ******@.Guoxing Zhu, Department ofOrthopedics, Wuxi No. 2 People’sHospital, 68 Zhongshan Road, Wuxi214002, Jiangsu Province, China,guoxing-******@.doi:-: 2014-10-20Lin Gan, Minquan Qian, Keqin Shi, Gang Chen, Yanglin Gu, Wei Du, Guoxing ZhuIntroductionPeripheral nerve injury monly caused by accidentaltrauma, pression or iatrogenic injury (Wu et al.,2012). Such injury can induce temporary or permanentneurapraxia, and may seriously affect a patient’s quality oflife and ability to work. Drug treatment can improve neu-rological function after peripheral nerve damage, especiallycrush injury (Jacob et al., 2000; Xie et al., 2001; Gu et al.,2011). After peripheral nerve injury in adult mammals, aslow increase in the neuronal expression of neurotrophicfactor can be observed from 7 days after injury. Axonal re-generation at the proximal stump of the injury site is alsovery slow, and even after nerve suturing, axons may take upto 1 month