红酒介绍redwine.ppt.ppt

Red Wine and its Cardiovascular Effects
By: Mary C. Lawrence
Why the interest in red wine?
“French Paradox”
Loaded with natural health aids
Cholesterol Detoxifier
Anticoagulant
Artery Relaxant
Lowest rate of cardiac disease mortality
Fairly high intake of saturated fatty acids
How Antioxidants Work
Saturated fats and oils contain many double bonds or 30 hydrogen which are easily targeted for auto-oxidation
Auto-oxidation leads to hydroperoxides which can dissociate rapidly because the RO-OR bond dissociation energy is ~35 kcal/mol which is lower than most bonds
Auto-oxidation
R3CH + O-O R3COOH
R3CO-OH R3CO + OH
How Antioxidants Work cont.
Antioxidants inhibit auto-oxidation of the free radical groups
Antioxidants are usually pounds (aromatic ring with -OH group attached)
Phenols make good radical scavengers because the radical products are resonance-stabilized so they are then non-pare to other radicals
Wine Antioxidants
Phenolic Acids
Flavonols
Gallic acid
Quercetin
Benzoic acid
Wine Antioxidants cont.
Anthocyanins
Malvidin
Cyanidin
Wine Antioxidants cont.
Condensed Tannins
Wine as a cholesterol detoxifier
antioxidants help inhibit the oxidation and cytotocicity of low-density lipoprotiens
Taken from
LDL Uptake into cells
1. LDL binds to receptor
2. Receptor-plex internalized by endocytosis
3. Fusion with lysosomes--LDL hydrolyzed
4. Regulatory actions
Taken from Stryer Ed. 2 (p. 472)
How LDL is Oxidized
Taken from