小鼠皮肤三相过敏反应模型研究进展.doc

小鼠皮肤三相过敏反应模型的研究进展
彭程,车慧,胡晋红* 基金项目:上海市科委中药现代化重大专项基金(No:04DZ19846);上海市卫生局科研课题基金(No:054099);
上海市科委基础研究重点项目(No:05JC14016)
作者简介: 彭程(1971年4月-),女,主管药师,皮肤药理学硕士研究生。Tel:021-25070674,E-mail:topengcheng@。
胡晋红(1949年5月-),女,教授,博士生导师,研究方向:皮肤药理学。Tel:(Fax):021-25070665,E-mail:******@smmu.。
(第二军医大学第一附属医院药学部,上海 200433)
摘要:由anti-DNP IgE单克隆抗体致敏、DNFB激发而形成的IgE介导的小鼠皮肤过敏反应模型1983年首次被发现,历经了两相(速发相、迟发相)到三相(速发相、迟发相、超迟发相)过敏反应模型的建立、研究、应用,以及造模方法的优化,使此三相皮肤过敏反应模型逐步健全。三相过敏反应的免疫机制各有不同,现已将此模型应用到过敏反应免疫机理的研究、抗过敏药物的药效学研究、过敏性疾病治疗方法的探索等方面。
关键词:三相过敏反应;抗-DNP IgE单克隆抗体;模型;皮肤过敏反应
Study and Application of the Model of IgE-dependent Triphasic Cutaneous Reaction in Mice
PENG cheng, HU Jin-hong*,ZHU Quan-gang, LIU ji-yong, WANG Jing, LIU yan-xia
(Dept of Pharmacy, Changhai Hospital, the Second Military Medical University, Shanghai 200433,China)
Abstract: The model of IgE-dependent cutaneous reaction in mice was found in 1983,which sensitized with anti-DNP IgE mAb and challenged with DNFB. This model turned into triphasic reaction (IPR, LPR and vLPR) from biphasic reaction (IPR, LPR) .The immunologic mechanism of the triphasic cutaneous reaction was different respectively, which was described in this article. This model had been applicated in some investigations, such as the immunological mechanism of hypersensitive response, pharmacodynamics in antiallergic drugs and the therapy in anaphylactic disease and so on.
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