常见信号通路.ppt

重要的几种信号通路介绍MAPK信号通路JAK-STAT信号通路Wnt信号通路TGF-信号通路NF-B信号通路PI3K-AKT信号通路MAPK信号通路丝裂原活化蛋白激酶MAPK信号级联反应StimulusGrowthfactors,Mitogen,GPCRp38MAPKStress,GPCR,Inflammatorycytokines,GrowthfactorsStress,Growthfactors,Mitogen,GPCRMEKK1,4,MLK3,ASK1MEKK2,3,Tpl2MLK3,TAK,DLKRaf,Mos,Tpl2MKK3/6MEK1/2MKK4/7MEK5ERK1/2MAPKKKGrowth,Differentiation,DevelopmentInflammation,Apoptosis,Growth,DifferentiationGrowth,Differentiation,DevelopmentERK5/BMK1JNK1,2,3MAPKKMAPKBiologicalresponses丝裂原活化蛋白激酶(MAPK)信号转导通路Ser/Thr蛋白激酶受细胞外刺激而激活通路组成—三级激酶模式在所有真核细胞中高度保守调节多种重要的细胞生理/病理过程MAPK是信号从细胞表面→核内的重要传递者。哺乳动物细胞中:MAPK激酶激酶(MKKK,MAP3K) 20种MAPK激酶(MKK,MAP2K) 7种MAPK 12种一、MAPK信号通路的成员MAPK其他名称与ERK2的同源性%同一亚族成员序列相似性%ERK1p44MAPK88ERK2p42MAPK100ERK3αp62ratERK343100ERK3βhumanERK34274JNK1SAPKγ4087JNK2SAPKα41100JNK3SAPKβ4088哺乳动物MAPKMAPK其他名称与ERK2的同源性%同一亚族成员序列相似性%p38αp38CSBP50100p38βp38-24775p38γERK6SAPK34462p38δSAPK44264ERK5BMK151ERK741哺乳动物MAPKMKK(MAP2K):MEK(MAPK/ERKkinase)MEK4MEK6MEK3MEK7MEK5MEK2MEK1MKKMKKK(MAP3K):Raf亚家族:A-Raf,B-Raf,Raf1MEKK亚家族:MEKK1-4ASK1,Tpl2亚家族MST,SPRK,MUK,TAK1,MOS等MAPK信号通路作用模式