,樊晖,田原,陈缤,付勇强,,王英,指导:孙科峰(,辽宁沈阳110013;,辽宁沈阳110032)摘要:以变应性鼻炎小鼠为模型,采用均匀设计法,探讨加味麻黄附子细辛汤组方合理性及配比剂量。结果各药物在鼻敏康组方中的重要性地位依次为:附子>黄芪>防风>麻黄>细辛>白术;附子、黄芪、防风、细辛的用量与疗效呈正相关,即用量较大时疗效较好;麻黄、白术的用量与疗效呈负相关,即用量较少时疗效较好;麻黄与细辛、黄芪与附子间的交互作用呈正相关;麻黄与黄芪、黄芪与白术间的交互作用呈负相关,组方时应适当增加或减少相关药物的用量。关键词:加味麻黄附子细辛汤;变应性鼻炎;均匀设计中图分类号::A文章编号:1673—7717(2008)01—0123—02StudyOI3ProportioningofModifiedEphedraAsarumHerbAconiteDecoctionFormulaandDose[’FANHui,1f1ANYuan2CHENBin2FUYor~-qhng2WANGHui,WANGYi,advisor:SUNKe-feng2(,Shongyang110013,Liaoning,China;,Shenyang110032,Liaoning,China)Abstract:UsingethologyofaverageincidenceofallergicrhinitismiceC57BL6asindex,uniformdesignisadoptedtooptimizeformulaanddoseofmodifiedephedraa$(31":aconite>astragahs>Saposhnikoviadivaricata(Turez.)Schischk>ephedra>asal~unherb>atractyledesmacrocephala;aconite,astragalus,Saposhnikoviadivaricata(Turez.)Schischk,asartllnherbhavepositiverelationshipwiththenumberofgrab-bingnose,ephedra,atractyledesmacrocephalahavenegetiverelationshipwiththenumberofgrabbingnose;theinteractionofephedraandasarulnherb,astragahsandaconitearepositive;ephedraandastragalus,astragalusandSaposhnikoviadi-varicata(Turcz.)Schischka
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