黄连解毒汤传统饮片汤剂与配方颗粒汤剂中小檗碱的药动学的比较黄连解毒汤传统饮片汤剂与配方颗粒汤剂中小檗碱的药动学的比较中南约学2O1O年9月第8卷第9期CentralSouthPharmacy,.September2010,,李新中(,长沙410008:,长沙410078)摘要::Diamonsil(:1H(:X250rntll,5"m);柱温:35C;流速1mI,?min;?IKH!P().冰醋酸(40:60:1,v/v),,高剂量组的2种汤剂后,大鼠血浆中小檗碱(分别为:?mI,?mI,??1I;At分别为:l0.,,』g?h?YllI,*g?h?mI,?h?m1;.,,2种汤剂中盐酸小檗碱的(,f…AU一,以及药时曲线均无显着差异性,:黄连解毒汤;传统饮片汤剂;配方颗粒汤剂;药动学中图分类号:,R9l7文献标识码:A文章编号:1672—2981(2010)09064504dot:1().3969/.】672—()l().'...,.'(,Cem1"oISouthUniuersily,Changsha410008;(iencs,(/entral&ruthUniversity,(Thangsha410078)Abstract:ObjectiveT()—arlK)iisi1C】H(×250nlYn,5n)?andtheflowrKtewas1mI?()?IKHPO1glacialaceticacid(40:60:1),andthewav&lengthw',,(??mL,,?.,'nil-/*g?h?mI,?h?mIrespec—【l,(l,_1..AU(一,and('_Tcurvesbetweenthetwodecoctionshavenosig-一nifiean【ldifferer{Ice,:HuanglianJieduTang;1raditbnMslicedecoction;dispensinggranuledecoction;pharmacodynamics黄连解毒汤始载于唐代于焘《外台秘要》(引崔氏),由黄连,,黄十自,{『,,结果显示2种汤剂化学成分及约效学方而具有一致件,,,采川高效液相法测定大鼠f札浆中小檗碱的血药浓度,比较2种汤剂中小檗碱在等剂量灌胃给药后大鼠血浆中的药物动力学参数,以期揭示黄连解毒汤配方颗粒汤
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