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免疫球蛋白1.pptx

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Immunoglobulins:StructureandFunctionDefinition:GlycoproteinmoleculesthatareproducedbyplasmacellsinresponsetoanimmunogenandwhichfunctionasantibodiesImmuneserumAgadsorbedserum12+-plementBindingtovariouscells(UsuallyrequireAgbinding)AgbindingCanresultinprotectionValencyBasicImmunoglobulinStructureImmunoglobulins-heterogeneousMyelomaproteins-homogeneousimmunoglobulinsImmunoglobulinStructureHeavy&LightChainsDisulfidebondsInter-chainIntra-chainCH1VLCLVHCH2CH3HingeRegionCarbohydrateDisulfidebondImmunoglobulinStructureVariable&ConstantRegionsVL&CLVH&CHHingeRegionCH1VLCLVHCH2CH3HingeRegionCarbohydrateDisulfidebondImmunoglobulinStructureDomainsVL&CLVH&CH1-CH3 (orCH4)haridesCH1VLCLVHCH2CH3HingeRegionCarbohydrateDisulfidebondIgGmoleculeUsedwithpermissionfrom:,ImmunologyDivision,DepartmentofPathologyCambridgeUniversity,Cambridge,EnglandStructureoftheVariableRegionHypervariable(HVR)plimentaritydeterminingregions(CDR)HVR3FR1FR2FR3FR4HVR1HVR2VariabilityIndex257550100Aminoacidresidue150100500FrameworkregionsImmunoglobulinFragments:Structure/FunctionRelationshipsFabAgbindingValence=1SpecifictydeterminedbyVHandVLPapainFcFabFcEffectorfunctionsImmunoglobulinFragments:Structure/plementBindingSitePlacentalTransferBindingtoFcReceptors

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