咪唑斯汀缓释片的释放度研究孙建绪1刘亚琴2胡音1高永良1(1军事医学科学院毒物药物研究所,北京100850;2国家发改委药品价格评审中心,北京100045)[摘要]目的:对制备的咪唑斯汀缓释片进行体外释放度研究。方法:采用比较法对不同的释放介质进行考察。结果:、%、5小时大于80%。结论:本品在上述三种介质中体外释放基本一致,其释放度不受释放介质pH值的影响,达到了设计要求。[关键词]咪唑斯汀缓释片处方释放度含量测定[中图分类号][文献标识码][文章编号]InvitroevaluationofSustained-releaseTabletofMizolastineSUNJian-xu1LIUYa-qin2HUYin1GAOYong-liang1(,AcademyofMilitaryMedicalSciences,Beijing100850,China;,Beijing100045,China)[Abstract]Objective:Toevaluatedissolutioninvitroofsustained-:Thedissolutionbehaviorsofsustained-releasetabletofmizolastine,,purwaterPBS():Invitroevaluationindicatedthatitcanreleasemorethan60%aftertwohoursandmorethan80%﹒L-1HCL,purewater,PBS()solutionConclusion:Sustained-releasetabletofmizolastinewereexpectedtosustained-releaseeffectivenessonthisformulationandtechnology,andhaveagoodstability;thedevelopmentalresearchofsustained--independent.[Keywords]sustained-releasetabletofmizolastine;pharmaceuticalengineering;technology;formulation;contentassay咪唑斯汀(mizolastine)为非镇静性抗组胺药,用于抗过敏[1,2],其制剂由法国Sanofi-Synthelabo公司研制,外观为长椭圆形异型缓释片[3]。1998年在德国上市,相继又在比利时、丹
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