软膏实验讲义摘要.ppt

Preparation of ointments Preparation of ointments ? Purpose ? Introduction ? Equipments and materials ? Procedures ? Experimental instructions ? Questions Purpose ?? To master the preparations of different To master the preparations of different type type s of bases of ointments s of bases of ointments ?? To understand the evaluation of the To understand the evaluation of the ointments ointments Introduction ? Ointments are semi-solid preparations made of medicaments and suitable bases, which are intended for external application to the skin. ? Bases: oleaginous bases, emulsion bases, and water-soluble bases. ? Preparation methods: incorporation method ( grinding and mixing ) , fusion method ( melting and mixing ) and emusification method . Equipments and Materials ? Equipments: Evaporating dish, water bath, electric furnace, analytical balance, thermometer, etc. ? Materials: c etyl alcohol , s tearic acid , liquid paraffin , white petrolatum, nipagin esters , g lycerol monostearate , sodium lauryl sulfate , t riethanolamine , glycerin, d istilled water , etc. Procedures c etyl alcohol s tearic acid g liquid paraffin white petrolatum nipagin g lycerol monostearate sodium lauryl sulfate t riethanolamine glycerin d istilled water add up to 30mL 1 1、、 O/W emulsion base O/W emulsion base Formul a oleaginous phase aque ous phase 1. 1. Melt the oleaginous phase in an evaporating dish Melt the oleaginous phase in an evaporating dish using a water bath at the temperature of 75-80 using a water bath at the temperature of 75-80 ℃℃. . 2. 2. Dissolve the water-soluble ingredients in the Dissolve the water-soluble ingredients in the calculated amount of water in an evaporating dish calculated amount of water in an evaporating dish or a beaker and heat the solution to 75-80 or a beaker and heat the solution to 75-80 ℃