1α,25-dihydroxy-2β(3-hydroxypropoxy)vitamin d3 (ed-71)…：1α，25-dihydroxy-2β（3-hydroxypropoxy）维生素d3（ed-71）….pdf

1 α,25-Dihydroxy-2 β(3-hydroxypropoxy)vitamin D 3(ED-71) suppressed callus remodeling but did not interfere with fracture healing in rat femora Yongping Cao a,b, Satoshi Mori a, ?, Tasuku Mashiba a, Yoshio Kaji a, Takeshi Manabe a , Ken Iwata a, Kensaku Miyamoto a, Satoshi Komatsubara a, Tetsuji Yamamoto a aDepartment of Orthopedic Surgery, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun Kagawa 761-0793, Japan bDepartment of Orthopedic Surgery, First Hospital of Peking University, Beijing, China Received 31 March 2006; revised 21 June 2006; accepted 24 July 2006 Available online 7 September 2006 Abstract Introduction: Because osteoporotic patients are prone to fractures, it must be considered whether or not patients undergoing drug therapies should discontinue treatment after sustaining a non-vertebral fracture. This study has tested the effect of novel active vitamin D 3analog, 1 α,25- dihydroxy-2 β(3-hydroxypropoxy)vitamin D 3(ED-71), on the fracture paring with a powerful anti-resorptive agent, alendronate, using a rat femoral fracture model. Materials and methods: Female SD rats ( n=201) allocated into 6 groups were treated with MCT-vehicle and ED-71 at and μ g/kg/day (EDL and EDH groups), and with saline-vehicle and alendronate at 5 and 10 μg/kg/day (ALL and ALH groups). After 4 weeks of pretreatment, osteotomy of the femur was