手性化合物论文.doc

.课题综述手性化合物的酶法合成与拆分系院药学院专业 09 制药工程学号 0945253233 姓名章传义. 二零一二年四十一月十五日. 摘要手性是三维物体的基本特性,手性又称不对称性。如果一个物体不能与其镜像重合,该物体就称手性物体。这两种互成镜像的形态被称为对映体,手性分子的立体构型即为对映体结构。由于手性化合物的两种对映异构体通常具有不同的生物活性,因此制备对映体纯的手性化合物在生命科学、药物化学、精细化学、材料化学等领域具有重要意义。其中酶法手性化合物的制备(包括酶法不对称合成及外消旋体的不对称合成)具有立体专一性强、拆分效率高、产生条件温和、无环境污染等特点,在化学工艺中的应用越来越广,主要在两个方面:第一方面作为常规催化剂, 合成高 . (对映体过量)值和好收率的单一对映体;第二个方面是用于消旋体拆分,就是用酶把两个对映体分离开来。[1]本文综述了以酶作为催化剂,进行手性化合物合成的研究进展。关键词:手性化合物;酶;合成与拆分. pound of pound of enzyme synthesis and splitting Abstract C hirality isa three-dimensional object of the basic characteristics, chirality palmtop asymmetry . If an object can't coincide with the mirror, The objects in the hands of the objects. The two mutually into the mirror of forms are called for the hands of terrorists and three-dimensional style for the construction pound of hand. the nature of the two businesses are often different from the body of the activity and prepare for the pure pounds in life science, medications chemical, fine chemistry , material chemical and other areas of great significance. these enzyme the hands of pound ( include preparation of the enzyme synthesis is symmetric and external and the synthesis of the asymmetry )a solid professional nature is strong, high efficiency, a mild conditions and environmental pollution and other features, The chemical process the application of more widely , primarily on two fronts : the first way as general catalyst , into high e. e.( to the body excessive ) value and that the yield to the body ofa single; the second aspect is to use the split, that use enzyme separation the two of the physical .The text summarize use enzyme as catalgst .conductmicroma about posite. Key Words : pound ; enzyme ; synthesis and split . 目录摘要..................................................................................................................................... I Abstract ...........................................................................................................................