儿科学：麻疹.ppt

Measles
麻疹
Measles is an acute respiratory contagious disease caused by measles virus
OVERVIEW (概述)
fever 发热
upper respiratory Inflammation 上呼吸道炎症
conjunctivitis 结合膜炎
Koplik’s spots Koplik’s斑
generalized maculo－papular rash 全身性斑丘
branny desquamation 脱屑
brownish discoloration 色素沉着
OVERVIEW
OVERVIEW
Purpose and requirement
measles virus 麻疹病毒
RNA-containing virus of the paramyxovirus family （副粘病毒）
only one serotype
15 genotypes 6 structure proteins
be rapidly inactivated by heat,light , and all kinds of desinfectant (消毒剂）
be stored indefinitely at low temperature
ETIOLOGY
electron micrograph
(N、P)
envelop
polymerase(L)
structure of MV
M protein
H
F
infectious source
patient 患者
infectious route
Droplet infection 飞沫传播
Contract infection 接触传播
susceptible population
general susceptibility 普遍易感性
life immunity 终生免疫
epidemical features
winter spring 6m-5y
EPIDEMIOLOGY
Respiratory epithelium regional lymph nodes
First viremia
Monocytes/Macrophage
Second viremia
Respiratory tract, conjunctiva, skin, etc
Virus elimination
Measles virus
1. Incubation period
10-14 days
2. Prodromal period
3-4 days

manifestation period
3-5 days
4. Convalescent period
3-5 days
*
PATHOGENESIS
PATHOGENY
网状内皮巨细胞
上皮巨细胞
多核巨细胞
multinucleated giant cell
reticuloendothelial giant cells
epithelial giant cells