地塞米松.pdf

British Journal of Anaesthesia 112 (3): 427–39 (2014)
Advance Access publication 10 January 2014 . doi:
Effects of dexamethasone as a local anaesthetic adjuvant for
brachial plexus block: a systematic review and meta-analysis
of randomized trials
S. Choi1*, R. Rodseth2,3,4 and C. J. L. McCartney1
1 Department of Anaesthesia, Sunnybrook Health Sciences Centre, University of Toronto, M3-200, 2075 Bayview Avenue, Toronto, ON, Canada
M4N 3M5
2 Perioperative Research Group, Department of Anaesthetics, Inkosi Albert Luthuli Central Hospital, Nelson R. Mandela School of Medicine,
University of KwaZulu-Natal, Durban, South Africa
3 Population Health Research Institute, McMaster University, Hamilton, Canada
4 Department of Outcomes Research, Cleveland Clinic, Cleveland, OH, USA
* Corresponding author. E-mail: stephen.******@
Background. Brachial plexus nerve blocks (BPBs) have analgesic and opioid sparing benefits for Downloaded from
Editor’s key points upper extremity surgery. Single-injection techniques are limited by the pharmacological duration
† In this systematic review and therapeutic index of local anaesthetics (LAs). Continuous catheter techniques, while
of 9 studies and 801 effective can present management challenges. Off-label use of perineural dexamethasone
patients, the authors as an LA adjuvant has been utilized to prolong single-injection techniques. The objectives of
/
demonstrate the reliable this systematic review and meta-analysis are to assess the contemporary literature and
prolongation of sensory quantify the effects of dexamethasone on BPB.
and motor block after Methods. The authors searched for randomized, placebo-controlled trial