suzuki reaction-裴浩.docx

Suzuki coupling 0909403059 Phao 2012/05/08 T he palladium-catalyzed cross-coupling reaction pounds anic halides or triflates provides a powerful and general method for the formation of carbon-carbon bonds known as the Suzuki -reaction. M echanism of the Suzuki reaction is best described bya catalytic cycle: a) Oxidative addition — Reaction of the ponent with a palladium-(0) complex to give a palladium-(II) species. b) Transmetallation — Transfer of substituent R0 from boron to the palladium center, thus generating a palladium-(II) species that contains both the substituent R and R0 that are to be coupled. c) Reductive elimination — to yield the coupling product and the regenerated catalytically active palladium-(0) complex .A dvantage :? mild reaction conditions; ? commercial availability of many boronic acids; ? the anic by-products are easily removed from the reaction mixture, making the reaction suitable for industrial processes; ? boronic acids are environmentally safer and much less toxic anostannanes; ? starting materials tolerate a wide variety of functional groups, and they are unaffected by water; 6) the coupling is gener