顺铂+IL -2 胸腔内灌注治疗老年晚期肺腺癌恶性胸腔积液【摘要】目的: 观察顺铂+il-2 胸腔内灌注联合培美曲塞全身化疗治疗老年晚期肺腺癌恶性胸腔积液的临床疗效及毒副反应。方法:老年肺腺癌并胸腔积液患者共 51 例,采用顺铂 40 mg/m2 及 il-2150 万u 胸腔灌注保留,每周一次,共 2 周,同时应用培美曲塞,第1天,每3 周重复, 完成 2 个周期。治疗第 4 周评价疗效及毒副作用。结果: 51 例患者均可评价疗效,完全缓解者 16例,部分缓解者 25 例,无效者 6 例,其有效率为 % ,完全缓解率 % 。结论:顺铂+il-2 胸腔内灌注联合培美曲塞全身化疗治疗老年晚期肺腺癌恶性胸腔积液治疗的方法疗效显著,毒性反应轻, 临床使用安全。【关键词】顺铂; il-2 ; 培美曲塞; 老年; 肺腺癌; 胸腔积液 clinical observation of cisplatin + il-2 intrathoracic perfusion joint pemetrexed disodium systemic chemotherapy for elderly patients with advanced malignant pleural effusion of lung cancer/wang yong-ming , jing li-jun , feng gui-xin , et al.//medical innovation of china , 2012 ,9( 31): 018-019 【 abstract 】 objective : observation on cisplatin and il-2 intrathoracic bined with pemetrexed disodium systemic chemotherapy for elderly patients with advanced malignant pleural effusion of lung adenocarcinoma ’s clinical efficacy and side : the lung adenocarcinoma in elderly patients with pleural effusion a total of 51 cases , the intrathoracic injection of cisplatin ( 40 mg/m2 ) and il-2 ( million u) once a week for 2 weeks were given. at the same time , pemetrexed disodium for injection ( 500 mg/m2 ), the first day , every 3 weeks repeated , two cycles. the 4th week for evaluating efficacy and side : 51 patients could be evaluated the effects , 16 cases pletely alleviated ,a part
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