CongenitalHypothyroidism新生儿甲低(1).pptx

Congenital Hypothyroidism
Qi xiaohong
Pediatric Dept.
1
TH
the critical hormone for CNS maturation .
human
birth
ount of pntiiut^ tnin 5mo
3
neurons
During brain development,
are added
every minute!!]
1 weeks
11 weeks
A months
5 weeks
The Incidence of Congenital Hypothyroidism in China
城市
筛查人数
发生率
北京
15 500
1/7750
天津
26 081
1/5216
上海
68 939
1/5303
福建
51 086
1/2689
广州
251 880
1/4296
河南
41 000
1/6833
6
THYROID GLAND
Thyroid Hormone (T3 T4
yDOthalamic・Pituitary・Thyroid Axis
HYPOTHALAMUS
PITUITARY
TSHj@
CLASSIFICATION
J. PRIMARY (THYROID GLAND)
HYPOTHYROIDISM -一- SECONDARY (PITUITARY GLAND)
TERTIARY (HYPOTHALAMUS)
CONGENITAL ——-SPORRADIC
(CRETINISM)'^ ENDEMIC HYPOTHYROIDISM "
IN CHILDREN
4 ACQUIRED : after 2yr
(JUVENILE )
8
CLASSIFICATION
■ Endemic CH:hypothyroidism secondary to iodine deficiency in defined geographic areas.
■ Sporadic CH :caused by congenital defects of thyroid glands in nonendemic areas.
9
Congenital Hypothyroidism
EITIOLOGY
Thyroid developmental defects Accounts for 90% of CH
Aplasia,hypoplasia maldecent of thyroid
(2) Defects in thyroid hormone synthesis
Iodine transport defect
Thyroid peroxidase defect
Thyroglobulin synthesis defect Deiodination defect
10