新生儿肌张力低下的临床方法.ppt

新生儿肌张力低下的临床方法
Neonatal Hypotonia
Central Causes
Cerebral palsy
Hypoxic ischemic encephalopathy
Intracranial hemorrhage
Cerebral malformations
Chromosomal abnormalities ( 21, Prader-Willi syndrome)
Congenital infection TORCH
Acquired infections
Peroxisomal disorders
Drug effects (. benzodiazepines)
新生儿肌张力低下的临床方法
Neonatal Hypotonia
Spinal cord
Birth trauma (especially Breech delivery)
Syringomyelia
新生儿肌张力低下的临床方法
Neonatal Hypotonia
Anterior Horn Cell
Spinal Muscular Atrophy
Traumatic myelopathy
新生儿肌张力低下的临床方法
Neonatal Hypotonia
Neuromuscular junction
Congenital myasthenia gravis
Transient acquired neonatal myasthenia
Infantile botulism
新生儿肌张力低下的临床方法
Neonatal Hypotonia
Muscle
Muscular dystrophies (congenital myotonic dystrophy)
Congenital myopathies (. central core disease)
新生儿肌张力低下的临床方法
Neonatal Hypotonia
Peripheral nerves
Hereditary sensory motor neuropathies
Charcot-Marie-Tooth disease
新生儿肌张力低下的临床方法
Neonatal Hypotonia
Metabolic myopathies
Acid maltase deficiency
Carnitine deficiency
Cytochrome-c-oxidase deficiency
新生儿肌张力低下的临床方法
Neonatal Hypotonia
History
Any significant family history
Affected parents
Siblings
Consanguinity
Stillbirths
Childhood deaths
新生儿肌张力低下的临床方法
Neonatal Hypotonia
History
Maternal disease
Diabetes
Epilepsy
Myotonic dystrophy
Pregnancy and delivery history
Drug or teratogen exposure
Decreased fetal movements
Abnormal presentation
Polyhydramnios/ oligohydramnios
新生儿肌张力低下的临床方法