内科学课件：16 间质性肺炎.ppt

Interstitial Lung Diseases(ILDs)
Case
Female, 52 years old
Chief Complaint
Shortness of breath for 2 months
Clinical Presentation
Cough with minimal sputum
Muscle and joint pains
Chest CT
Examinations
Blood Routine
WBC *10^9/L, N *10^9/L
Lung Function
FVC: 70%, FEV1:%, FEV1/FVC 80%, TLCO %
Slight restrictive ventilation dysfunction,
moderately decreased diffusion capacity
Autoantibodies
Anti-JO-1 (+), ANA 1:100
Creatine kinases
CK 532U/L, CK-MB subtype 28U/L, CK-MM subtype
Diagnosis?
ILD
ILD associated with connective tissue disorders
(CTD)
Multiple dematomyositis
Introduction
ILDs represent a large number of conditions that involve the parenchyma of the lung-the alveoli, the alveolar epithelium, the capillary endothelium, and the spaces between these structures, as well as the perivascular and lymphatic tissues.
A heterogeneous group of disorders
More than 200 entities
Difficult to classify