ros-dependent caspase-9 activation in hypoxic cell death论文.pdf

FEBS Letters 549 (2003) 94^98 FEBS 27507
ROS-dependent caspase-9 activation in hypoxic cell death
Jee-Youn Kim, Jae-Hoon ParkÃ
Department of Pathology, College of Medicine, Kyung Hee University, Seoul 130-701, South Korea
Received 3 April 2003; revised 1 July 2003; accepted 4 July 2003
First published online 22 July 2003
Edited by Vladimir Skulachev
positions in the apoptotic cascades [8]. The initiator caspases
Abstract Mitochondria are known to play a fundamental role
in apoptosis by releasing apoptogenic molecules such as cyto- are activated in the earlier phase of apoptosis and cleave ef-
chrome c into the cytoplasm, thereby sequentially activating fector caspases into active forms, which are responsible for
initiator caspase-9. However, the mechanisms of cytochrome c dismantling cells [5]. Activation cascades of initiator caspases
release or caspase-9 activation in response to hypoxia are un- have been delineated into two forms, death receptor-associ-
clear. In this report, we show that caspase-9 is activated by ated p