秦岭柴胡抗大鼠肝纤维化的研究.pdf

EffectsofAcanthopanaxsenticosusonsleepandgeneexpressionprofilesofsleep-deprivateddrosophila XuGuanghui1,2 LiTingli2 1XiamenMedicalResearchInstitute,Xiamen361008 2HeilongjiangUniversityofTraditionalChineseMedicine,Harbin150040 Objective:TostudytheeffectsofAcanthopanaxsenticosusonsleepandgeneexpressionprofilesofsleep- ods:Underthestandardconditionsofcostanttemperature,humidity,automaticallycontrolledlighting,aninfrareddrosophilaactivitymonitor system(DAMS)wasusedtomonitorthesleepingdataofdrosophila,andthedose-effectandtime-effectofAcanthopanaxsenticosusonimpro vingsleepwasstudiedin7-day-olddrosophila;then,effectsofAcanthopanaxsenticosusongeneexpressionprofilesofsleep-deprivateddro :1%drugmediumfordose,≥3daysfordeliverytimeisbestforimprovingsleep ofdrsophila;Acanthopanaxsenticosus(concentrationof1%,administration4days)canchangedexpressionof685genesintheheadoffly, 188geneswereup-regulated,and497genesweredown-:Acanthopanaxsenticosuscanimprovingsleepofdrosophila, anism. Acanthopanaxsenticosus(刺五加);drosophila;sleepdeprivation;microarray 秦岭柴胡抗大鼠肝纤维化的研究刘阿萍1景万燕2李敏1 1陕西中医学院药学院,咸阳712046 2榆林市横山县卫生局,横山719200 目的:观察秦岭柴胡水煎液对复合因素所致大鼠肝纤维化的作用。方法:制备四氯化碳、酒精以及高脂饲料等复合因素所致肝纤维化模型,将24只大鼠,随机分为:秦岭柴胡水煎液组,肝纤维化模型组,空白对照组。给药组连续7天灌胃秦岭柴胡水煎液(),观察秦岭柴胡水煎液对肝纤维化大鼠血清中谷草转氨酶(AST)、透明质酸(HA)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(Ⅳ-C)的影响,探讨秦岭柴胡