自体免疫疾病
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器官特异性
非器官特异性
自体免疫疾病
肌肉
肾脏
皮肤
关节
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Pathological Factors in Rheumatic Disorders
Rheumatic diseases are multisystem disorders caused by tissue damage resulting from autoantibodies, cytotoxic T lymphocytes, complement-fixing immune complex deposition, and inflammatory mediators
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Inflammatory Parameters
ESR
Acute phase reactants
Immunoglobulins
Complement components
Inflammatory mediators: cytokines, prostanoids
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ESR are determined by the three forces
Surface free energy (Van de Waal＇s force):cohesive force
Electrical charge associated with RBC: repulsive force
Dielectric constant of the medium: dissipates the force
第九页，课件共59页
Calculation Equation for ESR
Vs=2/9x(Ps-PL)R2/n x g
Vs= the limiting velocity of the sphere
R= the radius of the sphere
Ps and PL= the densities of the sphere and of the liquid
g= the acceleration due to gravity
n= the viscosity of the liquid
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