甘氨双唑钠对局部晚期非小细胞肺癌放射增敏作用的疗效观察.doc

甘氨双唑钠对局部晚期非小细胞肺癌放射增敏作用的疗效观察.doc甘氨双喳钠对局部晚期非小细胞肺癌放射增敏作用的疗效观察
［摘要］目的:探讨甘氨双哇钠(CMNa)对III期肺癌的放射增敏作用及不良反应。方法: 采用随机分组的方法将经病理学确诊的III期非小细胞肺癌(NSCLC)患者分为实验组(A组，放 疗加甘氨双哇钠)及对照组(B组,单纯放疗)。两组放疗方法均一样。A组在放疗同时，加用 CMNa(800 mg/m2),每周3次,至疗程结束;B组为单纯放疗，评价两组疗效及观察不良反应。结 果:A组的CR+PR为82. 6%(19/23),显著高于B组的52. 2%(12/23), P<0. 05,差异有统计学意义。 两组的不良反应比较,P>0. 05,差异无统计学意义。结论:甘氨双哇钠对局部晚期非小细胞肺癌 有放射增敏作用,可提高有效率(CR+PR),但不增加不良反应。
［关键词］非小细胞肺癌;甘氨双哩钠;放射治疗;放射增敏剂
［中图分类号］R734. 2 ［文献标识码］A ［文章编号］1674-4721 (2010)03 (b) -020-02
Clinical observations of radiosensitivity on NSCLC by CMNa
LIU Jianmin, K0U Yanli, WANG Hui
(Department of Radiation, Luoyang Third People' s Hospital, Luoyang471000, China)
［Abstract］ Objective: To observe the sensitization and adverse reaction of Metronidazol Amino AcidiumNatricum(CMNa) in radiotherapy for III stage non-small cell lung carcinoma(NSCLC). Methods: Forty-six patients were enrolled into two groups. 23 cases in the test group received concurent CMNa, 800 mg/m2 three times a week, ivgtt, radiotherapy. 23 cases in the control group received radiotherapy alone. Results: The overall response rate (CR+PR) in the test group was 82. 6%. Control group was %. The difference of overall rate between two groups was statically significant (P<0. 05). The rate of adverse reaction between the test group and control group was not different(P>). Conclusion: CMNa has remarkable sensitization effect on radiotherapy to NSCLC, but n