益气养阴化瘀解毒方联合DCF方案治疗中晚期胃癌的临床研究.pdf

摘要摘要目的t观察益气养阴,化瘀解毒法治疗中晚期胃癌的临床疗效,评价在此法指导下创制的中药复方对中晚期胃癌患者临床疗效,并考虑其安全性,阐述中医中药治疗中晚期胃癌的特色及优势,为规范中医疗效评价体系奠定基础。方法l采用随机对照的方法,以患者就诊顺序为编号(1-40),,然后将随机数字按升序排序,将排在第 ,,每组各20例。将40例中晚期胃癌患者随机分为2组, 治疗组和对照组各20例。两组均使用DCF方案化疗,21天为1个周期,化疗2周期,3 月后评价疗效。治疗组在化疗间歇期给予益气养阴化瘀解毒方水煎服,每日1剂。分别记录治疗前后的客观疗效、中医证候、毒副反应及生活质量改善等指标,结果采用统计学软件进行统计分析。结果:在中医证候积分方面,治疗组中医证候疗效有效19例(%),无效l例(%);对照组中医证候疗效有效9例(%),无效11例(%)。治疗组明显优于对照组()。在客观疗效、CEA、CAl99及毒副反应方面,两组比较差异无统计学意义()。在生活质量方面,治疗后的躯体功能、角色功能、社会功能、整体生活质量领域治疗组比对照组积分高,两组比较差异有统计学意义(P()。疲乏、恶心呕吐、食欲丧失等症状领域治疗组与对照组相比积分低,两组比较差异有统计学意义()。结论:益气养阴化瘀解毒方联合DCF化疗方案治疗中晚期胃癌,在提高患者生活质量、改善中医症状及毒副反应等方面优于单纯化疗。关键词:中晚期胃癌;益气养阴化瘀解毒方;DCF化疗方案;临床研究 Abstract Abstract Objectives:To observe the clinicalefficacy andsafety ofreplenishingqinourishing yin resolving stasisdetoxing formula on advanced middle-late gastric cancer the effectoftheChinese pound formula createdunder theguidance ofthismethod and elaborate the characteristicsand advantages ofmiddle-late ancer treatment by TraditionalChinese Medicine inorder tolay thefoundation forrelating theefficientevaluation system of Chinese medicine. Methods:A radomized-controlled approach was used thesequence of patients ordernumbers(1-40)and研t11 SPSS ,puter generated random numbers correspongding withthepatients therandom numbers inascending order' thepatients who were corresponding tothe l-20randomnumbers were in thetreatmentgroup, 2l一40 were inthe controlgroup,and eachgroup has casesofmiddle-lategastric cancer wererandomly dividedinto twogroups withtherandomized-controlled method:20 cases in thetreatmentgroup while theother groups use DCF model regimen,2 days for period of2cycles ofchemotherapy,therapeutic evaluations were taken inthetreatmentgroup tookreplenishingqinourishing yinresolving stasisdetoxing formu