伊伐布雷定的不良反应信号挖掘与评价.pdf

Anhui Medical and Pharmaceutical Journal 2021 Aug 25 8 1693
安 徽 医 药 jin ,China
To detect and evaluate the signal of adverse drug reactions of ivabradine from the FDA public date program
Abstract： Objective
(openFDA), so as to provide references for the rational use of this drug in clinical practices. Disproportionality analysis with
Methods
reporting odds ratio (ROR) and proportional reporting ratio (PRR) was used to detect ADR signals of lenvatinib reports in the FDA Ad‐
verse Event Reporting System (FAERS) from April 15,2015 to November 17, 2020. Totally 63 ADR signals were obtained by
Results
both ROR and PRR method, 35 of which not shown in the specification and label instruction of ivabradine. The analysis
Conclusion
of data inFAERS may provide ADR signals of ivabradine, and guidance for rational clinical use.
Drug related side effects and adverse reactions; Adverse drug reaction reporting systems; Ivabradine; Signal mining
Key words： -
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