2004 年 2 月第 21 卷第 1 期 天 津 中 医 药 Feb. 2004, Vol. 21 No. 1 T ianjin Jour nChinese herbs w as normal elec er at t ron_microscopicaly, fibrous t issue w as becom ing thin. T he content of HA w as obviously higher in model group than t hat of M healt hy group( P < 0. 01) . When compared w ith t he model rats, the cont ent of serum H A w as low er obviously in t he tw o e es groups t han that treated w it h JinSanE( P < 0. 05) . [ Conclusion] The Chinese herbs JinSanE has protect ive eff ect against n hi t he liver injury and can inhibit liver fibrosis induced by CCl4 exposure in rats. T he m echanisms m ay be consisted in its ability C of dow n_regulat ing TGF_ 1, smad3 and CT GF, and up_regulat ing Smad7 in rats. f
o Key words: JinS anE; hepatic fibrosis; rats; transform ing grow t
