中国当代医药 年 月第 卷第 期 2021 6 28 18 Mudan- jiang 157011, China [Abstract] Objective To explore the effect and safety of fractional CO2 laser combined with Tacrolimus Ointment on Methods vitiligo. A total of 60 patients with vitiligo admitted to Hongqi Hospital Affiliated Mudanjiang Medical Uni- versity from June 2018 to October 2019 were selected as the research objects and divided into the treatment group and the control group according to the random number table method, with 30 cases in each group. The control group was treated with Tacrolimus Ointment, and the treatment group was treated combined with fractional CO2 laser based on the control group. After 12 weeks of treatment, both skin lesions and adverse reactions were observed between the two Results groups. The total efficiency of the treatment group (%) was higher than that of the control group (%), the total skin lesions efficiency of the treatment group (%) was higher than that of the control group (%), the P differences were statistically significant ( <). There were no serious adverse reactions were observed in both groups. Conclusion Fractional CO2 las