伊布利特治疗心律失常的电生理机制及临床应用进展.pdf

伊布利特治疗心律失常的电生理机制及临床应用进展.pdf中华临床医师杂志(电子版)2016年3月第10卷第5期Chin J Clinicians(Electronic Edition),March1,2016,,【摘要】目前临床上能够有效且快速转复心房颤动(简称房颤)、心房扑动(简称房扑)的药物还比较少,伊布利特(ibutilide)转复房颤、房扑具有起效快,成功率高,安全性好的特点,其治疗心律失常的基本作用原理为延长动作电位时程和有效不应期来终止折返激动。伊布利特与普罗帕酮、胺碘酮、电复律、镁剂联用可提高临床疗效。【关键词】心律失常;伊布利特;心房颤动;心房扑动Electrophysiological mechanism and clinical application progress study on ibutilideLi Zelin, Zhang Ling, Tang Baopeng. Heart Center, the First Teaching Hospital of Xinjiang Medical University, Urumqi830054, China Corresponding author: TangBaopeng, Email: tangbaopeng@【Abstract】Effective and rapid of drugs of cardioversion of atrial fibrillation andatrial flutter are rare at present. Ibutilide is characterized by rapid effect in cardioversionof atrial fibrillation/atrial flutter, highconvertingrate and reliable basic mechanism of treating arrhythmia is prolongingaction potential duration and effective refractory period toterminate excitable reentry. Combined with propafenone, amiodarone, internal atrial cardioversion or magnesiumcould raisethe clinical effects.【Key words】Arrhythmia;Ibutilide;Atrial fibrillation; Atrial flutter伊布利特作为一种的速效、安全的新型Ⅲ类抗心律失常药物,于1996年在美国上市。经SFDA批准,于2007年11月在中国上市。F/AHA/HRS心房颤动(简称房颤)治疗指南,伊布利特作为转复房颤的一线药物被推荐使用(Ⅰ类,A级)[1]。转复作用机制与其他Ⅲ类抗心律失常药物不同,其独特的作用机制在于抑制复极时快钾通道外向电流的同时亦可促进平台期内向的慢钠电流和慢钙电流。本文就近年伊布利特的药理作用、临床应用及其有效性和安全性、同其他抗心律失常药物的疗效对