2021 年 9 月第 28 卷第 9 期 1257 h minocycline hydrochloride in the treatment of periodontitis complicated with pulp lesions. Methods 96 patients with periodontitis complicated with pulp lesions admitted to our hospital from January 2017 to December 2019 were selected and randomly divided into control group (n = 48, iodine glycerin combined with routine root canal therapy) and observation group (n = 48, Vitapex combined with minocycline hydrochloride). The periodontal conditions [gingival index (GI), probing depth of periodontal pocket (PD), plaque index (PLI), bleeding index (BI)], inflammatory factors [C-reactive protein (CRP), tumor necrosis factor (TNF-α)], total effective rate and incidence of adverse reactions were compared between the two groups. Results After treatment, the GI, PD, PLI, Bi, CRP and TNF-α levels of the two groups were lower than those before treatment, and the GI, PD, PLI, Bi, CRP and TNF-α levels of the observation group were lower than those of the control group (P <). The short-term and long-term incidences of adverse reactions in the observation group were lower than those in the control group (P <). The total effective rate of the observation group was higher than that of the control group (P <). Conclusions Vitapex combined with minocycline
