盐酸酚苄明片_1.doc

Dibenzyline Tablet s Manufacturer: WellSpring DESCRIPTION Each Dibenzyline tablet is imprinted WPC 001 and 10 mg and contains phenoxybenzamine hydrochloride, 10 mg. Inactive ingredients consist of benzyl alcohol, cetylpyridinium chloride, D&C Red No. 33, FD&C Red No. 3, FD&C Yellow No. 6, gelatin, lactose, sodium lauryl sulfate and trace amounts of other inactive ingredients. Dibenzyline isN -(2 Chloroethyl)- N -(1-methyl-2-phenoxyethyl)benzylamine hydrochloride: Phenoxybenzamine hydrochloride isa colorless, crystalline powder with a molecular weight of which melts between 136 ° and 141 ° C. It is soluble in water, alcohol and chloroform; insoluble in ether. CLINICAL PHARMACOLOGY Dibenzyline (phenoxybenzamine hydrochloride) isa long-acting, adrenergic, alpha -receptor blocking agent which can produce and maintain "chemical sympathectomy" by oral administration. It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures . It has no effect on the parasympathetic system. Twenty to 30 percent of orally administered phenoxybenzamine appears to be absorbed in the active form. 1 The half-life of orally administered phenoxybenzamine hydrochloride is not known; however, the half-life of intravenously administered drug is approximately 24 hours. Demonstrable effects with intravenous administration persist for at least 3 to4 d