抑那通治疗前列腺癌的新进展.ppt

AUA(2019)内分泌治疗新进展
RESULTS
Ten (53%) patients were on hormones for biochemical recurrence；
Two (10%) for metastatic disAUA(2019)内分泌治疗新进展
RESULTS
Ten (53%) patients were on hormones for biochemical recurrence；
Two (10%) for metastatic disease；
Seven (36%) as primary therapy.
AUA(2019)内分泌治疗新进展
RESULTS
Eleven (58%) patients had 2 consecutive rises in PSA;
The mean time to see two consecutive rises was 11 months.
AUA(2019)内分泌治疗新进展
RESULTS
The mean time off therapy prior to a rise in PSA above base line for all patients and those with 2 consecutive rises was and months respectively.
The mean base line PSA, mean PSA at one, and at two years off therapy was , , and 5ng/ml respectively.
Mean testosterone at base line, one, and two years off therapy was , 76ng/ml, and respectively.
AUA(2019)内分泌治疗新进展
RESULTS
Twelve (63%) patients had recovery of testosterone above 50ng/dl.
Four (21%) patients remained castrate off therapy a mean of 20 months.
The mean time to testosterone recovery was months.
Two (%) patients in the study have died. One death was attributed to prostate cancer.
AUA(2019)内分泌治疗新进展
CONCLUSION
The recovery of testosterone and significant elevations of PSA after long term LHRH agonist therapy is significantly delayed in most patients.
This helps to support the concept of intermittent androgen ablation which has benefits in quality of life and reduced cost of therapy.
Data on file
手术去势的副作用
增加心血管疾病和糖尿病发病率
Data on file
手术去势的副作用
增加骨折发病率
抑那通通过抑制雄性激素的作用而抑制大白鼠前列腺肿瘤的增殖
醋酸亮丙瑞林水溶液
（1日1次投药)
醋酸亮丙瑞林水溶液
（1日2次投药)
抑那通
（1月1次投药)
阉割
肿瘤移植后的天数
肿 瘤 体 积(cm)
对照
醋酸亮丙瑞林水溶液
1mg/kg/日（1日1次投药)
抑那通与睾丸切除术抗肿瘤作用比较
抑那通治疗前列腺癌的综合效果
抑那通治疗前列腺癌各病灶的疗效
抑那通改善前列腺癌各种症状的效果明显
抑那通治疗前列腺癌从起效到部分缓解的时间
间歇疗法与持续疗法患者生存率相当
Data on file
抑那通间歇疗法显著降低前列腺体积
第1周期
第2周期
前列腺体积变化比例(%)
Bruchovsky N, et al. Jul 15;107(2):389-95
抑那通间歇疗法迅速降低PSA值
到达PSA最低值所需时间(月)