2022 4 28 10 633 Contemporary Medicine Issue 当代医学 年 月第s with scarlet fever treated in our hospital from January 2018 to December 2019 were selected as the research subjects. They were divided into obser- vation group and control group according to the principle of random lot, with 150 cases in each group. The control group was treated with azithromy- cin and the observation group was treated with cefuroxime sodium. The symptom improvement time, clinical efficacy, incidence of adverse reactions, inflammatory factor level and immune function indexes were compared between the two groups. Results The antipyretic time ([±]d), cough disappearance time ([±]d), rale disappearance time ([±]d) and chest pain disappearance time ([±]d) in the observation group were shorter than those in the control group ([±]d, [±]d, [±]d, [±]d), the difference was statistically signifi- cant (P<); the total effective rate of the observation group was higher than that of the control group, and the incidence of adverse reactions was lower than that of the control group (P<). After treatment, IL-8 ([±]μg/L), IL-6 ([±]μg/L) and TNF-α ([±]μg/L) in the observation group were lower than those in the control group ([±]μg/L, [1