2022 年 4 月第 29 卷第 4 期 475 to different treatment methods. On the basis of routine symptomatic treatment, the observation group was treated with irbesartan combined with hydrochlorothiazide tablets, and the control group was treated with hydrochlorothiazide tablets. The therapeutic effect, blood pressure levels and vascular endothelial function were compared between the two groups. Results The total effective rate of treatment of the observation group was %, higher than % of the control group (P <). After treatment, the SBP and DBP levels of the observation group were lower than those of the control group, the serum NO level was higher than that of the control group, and the serum ET-1 level was lower than that of the control group (P <). Conclusions Irbesartan combined with hydrochlorothiazide tablets in the treatment of hypertension complicated with CHD has exact effect, which can effectively control the blood pressure and improve the vascular endothelial function of patients. [Key words] Irbesartan; Hydrochlorothiazide tablets; Hypertension; Coronary heart disease; Vascular endothelial function 高血压是多种心血管疾病的高危因素 血压持续增高可引 平均 年 对照组中男 例 女 例 年龄 袁
